It would have likely delighted the Prankster to no end to be considered a super-villain, thought he was not a direct physical threat to the Man of Steel.  He was, however, a hardened criminal with an incredible knack for criminal strategies that were notoriously clever and difficult to resolves.  Shortly after his first case, he re-appeared as a reformed man, sending letters of appreciation that got him invited to the homes of Metropolis' elite. While they wined and dined him, he quietly staged a series of robberies of their homes that they would never ascribed to him until Superman solved the puzzle.  The Prankster, however, escaped again (Action Comics 57). 

Throughout the 1940's, he bedeviled Superman, the police and the city of Metropolis will confusing crimes.  In 1943, he copyrighted the entire English Alphabet and demanded all publications pay him to use it.  He is immune to prosecution until he attempts to murder Clark Kent and Lois Lane and swindle his cohorts, who turn on him and he needs Superman to save him.  After a year on the lamb, the Prankster gets his first taste of jail (Superman #22).   He later engages in stock market swindles (Action #77),  attempts to humiliate Superman into leaving Metropolis (Action Comics #95) and robs the US Mint with ink the converts currency to blank paper (Action Comics #109).

Unlike many of Superman's foes, the Prankster was an extensive collaborator with other figures.  He attempted to cultivate common criminal Al Fresco as a subsidiary version of him but Fresco turned on him, adopting the criminal identity of The Trickster until Superman and The Prankster held bring him to heel (Superman #69).  In 1950, he and Alexi Luthor are recruited by Mr. Mxyzptlk in a scheme to humiliate Superman using a series of proxy facsimiles of themselves and those close to him like Lois Lane.  The ultimate act is an elaborate magic show in which Superman outfoxes the earthly criminal and tricks Mxyzptlk into saying his name backwards, banishing him back to the 5th dimension (Action #151). In 1954, he fell in with Luthor and the Toyman when all three criminals were out of jail but averse to challenge Superman and be defeated again.  Encountering each other by accident at an amusement park, the three decided to join forces, with each launching their best attack on Superman.  One by one, Superman thwart all three, the last failure being Luthors before the three criminals were carted off to jail and Toyman and The Prankster deriving pleasure that the arrogant Luthor had fared no better than they (Superman #88).

The Prankster activities after 1955 are unknown and whether he survived into the 21st century or left an heir has never been revealed.