Lissa Raven is thought to have had a happy childhood growing up the daughter of renowned psychologist Arthur Raven. She embraced her father’s work, growing up with extensive knowledge of physiology, psychology and other sciences.  She became his assistant and participated in his research until a fateful day in 1941.

Although her true identity was unknown as the time, she appeared in 1941 as a crime boss known as the Queen Bee.  She managed to convinced a number of different criminal factions to set aside their differences and follow a plan she had devised to rob a radium shipment bound for Europe.  In doing so, she quelled crime across the city as the mobs strategized her plan, causing routine crime to drop so low that Tex Thompson, known as Mr. America, to become suspicious.  Leaving his erstwhile sidekick Bob Daley behind, Mr. America set off to find the basis for the low crime rate.  Frustrated at not being included, Daley adopts the ridiculous guise of the Fat Man and begin to also patrol the city.

In a bumbling happenstance, Fat Man stumbles onto a gang meeting led by the Queen Bee. As he overhears their plans, he is discovered and rendered unconscious.  In the meantime, Mr. America has witnessed a hit-and-run and follows the trail to the Queen Bee’s hideout, just in time to see Fat Man leave by the window.  Barging in, Mr. America thrashes many of the gangsters but being started that the ringleader is a woman, is captured.  While the Queen Bee makes off for the radium with Fat Man secretly in tow, her goons move in on Mr. America, who quickly subdues them with his new flying carpet.  Rapidly catching up with the Queen, he and his new all Fat Man make short work of the hoods but the Queen herself throws a smoke bomb to cover her escape. Failing to capture the radium, she vows to fight again another day (Action Comics #42).

Several months later,  the disappearance of a famed inventor drew Mr. America to the western town of Rosston, Texas.  While there nearby mountains appeared to erupt into a volcano from which an iron giant emerged claiming to be the old Indian legend of Vo-Kan.  As the  towns people fled, Mr. American noticed the attention the giant paid to a warehouse and spying inside, discovers the Queen Bee has re-appeared.  Charging in, he defeats several of her henchmen before being defeated himself.  In the interim, Bob Daley has donned his disguise as Fat Man and followed his own trail into the mountains.  There he discovered the giant to be a metal robot in a rubber disguise and that the volcano is just phosphorous light tricks to mimic an eruption.   He managed to rescue the inventor as they flee, the encounter Mr. America who has made his own escape.  They blind the giant’s controls and lead it to a pool of benzol, which dissolves the rubber covering and exposed the vulnerable joints.  The giant crashes into the building where the Queen Bee is hiding but she escapes unseen (Action Comics #46).

In the months that followed, the Queen Bee orchestrated more daring schemes. She manufactured a replica of an ancient Viking ship which sailed into New York Harbor, spilling our an army of skeletal warriors in ancient armor.  Creating mayhem and fear, the monsters provided cover for yet another crime spree by the Queen Bee’s men.  All was undone when Mr. America and Fat Man intervened, revealing the warriors as actor midgets operating elaborate props (Action Comics #47). Shortly thereafter, the small town of Hamlin was targeted by the Queen Bee when she  posed as an elderly woman selling flowers.  A figure then appeared disguised as the legendry Pied Piper and suddenly important men holding the flowers appeared to follow the Piper into the bay, much as the original Pied had lured children into the Weser River.  In reality, the men were kidnapped to an underwater lair occupied by the Queen Bee and her gang and the Piper’s music affected only those who had handled her drugged flowers.  Again Mr. America and Fatman unraveled the mystery and again, the Queen Bee escaped (Action Comics #48).

Finally, in the summer of 1942, the Queen Bee is again on a murderous crime spree, running over the police as they attempt to stop a crime robbery.  Mister America rushes to the scene but the Queen is long gone. In the shadows, a hidden figure flings a rock into the scene with a note tied to it asking the hero for a secret meeting in the park.  Keeping the appointment, Mr. America discovers Arthur Raven.  The psychologist reveals that he had been working on a device to remove stress and worry from the minds of his anguished patients.  His daughter Lissa had insisted on testing it herself but instead of worry, the device removed her conscience.  She immediately adopted the identity of the Queen Bee and began the crime spree that had been baffling America for months. 

Convinced the device will build her an army of ruthless minions, the Queen Bee has one her goons trail her father and when he is thrashed by Mr. America, flees to warn the Queen.  In reality, his escape was part of a plan to lure the criminals to Dr. Raven’s lab where after a pitched battle, the henchmen are defeated and the Queen Bee is strapped into device to reverse the effects of the original.  The experiment is effective and Lissa Raven’s personality is restored with no memories of her time as the Queen Bee.  Satisfied that the identity of the Queen Bee is destroyed forever, Mr. America leaves the Ravens in peace and carts the henchmen off to jail (Action Comics #49).

Whether the identity of the Queen Bee was truly erased or every re-appeared as not been revealed.