The origins of the Earth-Two Secret Society of Super-Villains are unknown and it's existence or activities prior to 1980 has not been documented.  During the case in 1980, the Ultra-Humanite declared that the "Secret Society must live again!", implying the other versions had existed in the past on Earth-Two, as the Ultra-Humanite is not documented to have visited Earth-One.  The first documented case of this Society involved the recruitment of Brain Wave of the original Injustice Society so there may be some relationship between the two that has not been defined. Any relationship with the Secret Society of Earth-One has also not been defined.

The first documented case involving the Secret Society of Earth-Two occurred in the fall of 1981, when the Ultra-Humanite began re-forming the organization.  He recruited Brain Wave and tasked him with recruited representative criminals from Earth-One. He then began to reach out to several Earth-Two foes of Justice Society members including the retired Monocle. They two criminals then released the Psycho-Pirate from a Gotham City prison and parted ways, the Humanite locating the recently released Mist and the Monocle and Psycho-Pirate recruiting the Rag Doll in the midst of a Keystone City Robbery.  

Meanwhile, Killer Frost on Earth-One had been contacted by Brain Wave and begun a campaign to round up recruits from that world.  She found Phill Cobb, the Signalman, escaping from a Gotham Hospital and the Debbie Domaine living as a vagrant until she was reminded that she was the Cheetah.   The group then paid a visit on Jason Woodrue, a member of the Earth-One Secret Society who was supposedly trying to reform.  The Cheetah quickly strips him of his human guise, revealing the Floronic Man and the four rendezvous with Brain Wave to leave for Earth-Two.

Once there, the Ultra-Humanite revealed his full new form, a giant white ape housing the brain of Superman's oldest adversary.  He revealed a plan to capture ten heroes, five from each Earth and send them to Limbo.  He calculated  that the resulting cosmic imbalance would create a destablization force that removed all heroes from one of the Earth.  Which, he did not know, giving the villains from each world an equal chance.  He then charged each of them with ambushing  their old adversaries.  First blood fell to the Mist who captured Black Canary, followed by the Monocle's defeat of Hawkman and the Cheetah's defeat of Wonder Woman.

In rapid succession others fell.  The Psycho-Pirate, Rag Doll and Brain Wave captured Hourman, the Flash and Johnny Thunder on Earth-Two.  The Floronic Man, Signalman and Killer Frost, in turn, brought in the Atom, Batman and Firestorm from Earth-One.  Finally the Ultra-Humanite himself engaged the Superman of Earth-Two, bringing in the 10th hero.  Back in his mountain retreat, the heroes were loaded into tubes in a rotating device which spun rapidly into Limbo while the villains awaited the outcome.

Within moments, the world shifted and the Humanite was elated to see that Earth-Twi was unprotected.  The Earth-One villains realized that he had expected this outcome the whole time, using them for a supposed equal chance.  As they rise against him, a flick of a switch on one of his devices send them also to Limbo.